Nifty and Ryan have done similar. Just remember a speaker housing needs to be rigid, the stronger the better. The more energy that flexis the box or moves it in the car, the less is moving the cone. So really thick MDF, lots of cross bracing, maybe even fille/layer the box with fibreglass.
As for holding it in, why not remove the mounts and bolt it to the screw holes for the mounts?
Fronty no.4, pimp mobile Treg 3.2 LWB lifted 2.5"
Fronty no.5 2.8 swb hd coils +2" 31"machos.